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Humalog

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FDA Warning Letter to Eli Lilly re: instability of insulin Lispro (Humalog) crystals-10 February 2010
Reuters News story re: Lilly/Humalog Warning Letter-23 February 2010
Insulin hexamers must break down into dimers and monomers to be absorbed. [1]
Alterations to human insulin structure producing insulins lispro (Humalog) and aspart (NovoRapid/Novolog).


Humalog is an Eli Lilly fast-acting analog insulin also known as insulin lispro. [2] Insulin lispro has been altered from the human insulin molecule at positions #28 and #29 on the B insulin chain. The normal amino acids present at B-#28 and B-#29 are Proline (#B-28) and Lysine (B-#29); insulin lispro reverses this so that Lysine is found at B-#28 and Proline at B-#29. [3]

Human time activity profile for insulins lispro (Humalog) and aspart (Novolog/NovoRapid).

Inverting the normal Proline-Lysine sequence of human insulin at positions #28 & #29 on the B insulin chain created an analog insulin which has less tendency to form into hexamers (self-association). [4] Keeping the insulin from forming hexamers means that in dimer and monomer form, they are able to be absorbed faster and that means more rapid onset, peak and less duration.

Insulin lispro has been known to "wilt" easily when not constantly refrigerated. Those who have had bad vials report finding hazy or small particles on inspection. [5] Humalog degrades rapidly--it can be working well one day but not the next. [6]

Dr. Nelson of University of California-Davis said in his lecture at the Ohio State Endocrinology Symposium in 2006 that if the short-acting analog insulins have any role in feline and canine diabetes, it is not yet determined. [7]

A study of dogs from 1993-1994 using various fractions of Humalog mixes against human NPH/isophane insulin found only minor differences in the use of Humalog Mix as opposed to NPH/isophane insulin. [8] A 2009 study comparing Humalog (insulin lispro) to R insulin when used to treat canine ketoacidosis cases found this analog insulin to be safe and effective. [9]



Contents

Analog insulins: amino acid sequence

Analog insulins: pharmacokinetics


These are human activity profiles.

References

More Information

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